现货moradec AH-106-PB说明书

更新时间：2022-12-28

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现货moradec AH-106-PB说明书

αHFc CL PBD

抗人IgG Fc PBD抗体与可裂解连接子

目录号：AH-106-PB

αHFc CL PBD是抗人IgG Fc特异性抗体，与吡咯并二氮杂平（PBD）通过可裂解接头偶联。抗体部分是对人IgG的Fc区特异的多克隆抗体。吡咯并二氮卓（PBD）是一种细胞毒性小分子，它与DNA小凹槽结合，并与DNA的特定位点交叉连接。连接PBD和抗体的可裂解接头在细胞外液中是稳定的，但一旦缀合物通过内吞作用进入细胞，就会被内体中的组织蛋白酶裂解。

αHFc-CL-PBD

Anti-human IgG Fc-PBD Antibody with Cleavable Linker

Catalog Number: AH-106-PB

αHFc-CL-PBD is anti-human IgG Fc specific antibody conjugated to pyrrolobenzodiazepine (PBD) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. Pyrrolobenzodiazepine (PBD) is a cytotoxic small molecule which binds to DNA minor groove and cross-links specific sites of DNA. The cleavable linker connecting PBD to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis.

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